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Drugmakers plan to raise U.S. prices on at least 350 branded medications including vaccines against COVID, RSV and shingles and blockbuster cancer treatment Ibrance, even as the Trump administration pressures them for cuts, according to data provided exclusively by healthcare research firm 3 Axis Advisors. The number of price increases for 2026 is up from the same point last year, when drugmakers unveiled plans for raises on more than 250 drugs. The median of this year’s price hikes is around 4% in line with 2025. The increases do not reflect any rebates to pharmacy benefit managers and other discounts. DRUGMAKERS ALSO CUT SOME PRICES Drugmakers also plan to cut the list prices on around nine drugs. That includes a more than 40% cut for Boehringer Ingelheim’s diabetes drug Jardiance and three related treatments. Boehringer Ingelheim and Eli Lilly, which sell Jardiance together, did not immediately respond to requests for comment on the reason for the price cuts. Jardiance is among the 10 drugs for which the U.S. government negotiated a lower price for the Medicare program for people aged 65 and older in 2026. Under those negotiations, Boehringer and Lilly slashed the Jardiance price by two-thirds. U.S. patients currently pay by far the most for prescription medicines, often nearly three times more than in other developed nations, and Trump has been pressuring drugmakers to lower their prices to what patients pay in similarly wealthy nations. The increases on 350 medicines come even as Trump has struck deals with 14 drugmakers on prices of some of their medicines for the government’s Medicaid program for low-income Americans and for cash payers. Pfizer, Sanofi, Boehringer Ingelheim, Novartis and GSK are among those companies and also plan to raise prices on some drugs on January 1. “These deals are being announced as transformative when, in fact, they really just nibble around the margins in terms of what is really driving high prices for prescription drugs in the U.S.,” said Dr. Benjamin Rome, a health policy researcher at Brigham and Women’s Hospital in Boston. Rome said the companies seem to be maximizing prices while negotiating discounts behind the scenes with health and drug insurers and then setting yet another price for direct-to-consumer cash-pay sales. An HHS spokesman declined to comment. KEEPING UP WITH INFLATION Pfizer announced the most list price hikes, on around 80 different drugs including cancer drug Ibrance, migraine pill Nurtec, and COVID treatment Paxlovid, as well as some administered in hospitals such as morphine and hydromorphone. Most of Pfizer’s increases are below 10%, except for a 15% hike of COVID vaccine Comirnaty, while some of its relatively inexpensive hospital drugs saw more than four-fold increases. Pfizer said in a statement it had adjusted the average list price of its innovative medicines and vaccines for 2026 below the overall rate of inflation. “The modest increase is necessary to support investments that allow us to continue to discover and deliver new medicines as well as address increased costs throughout our business,” the company said. Larger U.S. drug price increases were once far more common. Drugmakers have scaled them back due to criticism from lawmakers and new government policies, such as penalizing companies that charge Medicare program prices that rise faster than inflation. European drugmaker GSK plans to increase prices on around 20 drugs and vaccines from 2% to 8.9%. The drugmaker said it is committed to reasonable prices and the hikes are needed to support scientific innovation. Sanofi and Novartis did not respond to requests for comment. More price hikes and cuts can be expected in early January, which is historically the biggest month for drugmakers to raise prices. 3 Axis is a consulting firm that works with pharmacist groups, health plans and some pharmaceutical industry-related groups on drug pricing and supply chain issues. It is a related entity to, and shares staff with, drug pricing non-profit 46brooklyn. Michael Erman, Reuters
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Zohran Mamdani was a trailblazing candidate whom many in his city of 8 million some with hope, some with trepidation expect to be a disruptive New York mayor. The democratic socialist’s plans for his first day in office on Thursday nod to his politics and priorities, without straying far from his predecessors with a sober official midnight oath-taking followed by a more celebratory ceremony in the afternoon. New York law spells out that four-year mayoral terms start on the January 1 after elections. To avoid any ambiguity about who’s in charge of America’s most populous city, it has become a tradition to hold a small midnight swearing-in. Mamdani has chosen as the site of his midnight oath the Old City Hall subway stop, which was decommissioned in the middle of the previous century and is accessible only a few times a year through guided tours. The subway site, according to Mamdanis transition team, reflects his “commitment to the working people who keep our city running every day.” Mamdani, a 34-year-old former state lawmaker, promised a freeze on rents and free buses and childcare, building a campaign around affordability issues that some have seen as a path forward for his Democratic Party around the country ahead of midterm elections. Mamdani inspired a record-breaking turnout of more than 2 million voters and took 50 percent, nearly 10 points ahead of Andrew Cuomo running as an independent and well ahead of Republican Curtis Sliwa. New York State Attorney General Letitia James, who was among Mamdani’s earliest prominent backers, was to administer the midnight oath to Mamdani. During the first administration of President Donald Trump, James began investigating his business practices in New York, resulting in a judge finding in 2024 that Trump fraudulently overstated his net worth to dupe lenders. The Trump administration has targeted James during his second term, accusing her of mortgage fraud. Grant Reeher, a Syracuse University political science professor, said the role James was to play in the inauguration sent a message to core supporters that Mamdani is “going to be independent of the president. INAUGURATION OF A NEW ERA The Uganda-born Mamdani, who will be New York City’s first Muslim mayor, has been a sharp critic of Trump on issues such as immigration and said his differences with the president were numerous after a warm White House meeting. But being sworn in by the state attorney general may say more about Mamdani’s political alliances than rivalries. In 2014 Bill de Blasio, whom Mamdani regards as the best New York City mayor of his lifetime, was sworn in privately by then-New York Attorney General Eric Schneiderman at the start of the first of his two terms. Senator Bernie Sanders, a progressive, Brooklyn-born Vermont senator whom Mamdani calls his inspiration, presided over de Blasio’s public inauguration ceremony in 2018 and will play a similar role for Mamdani. Liberal Democratic U.S. Representative Alexandria Ocasio-Cortez is also on the inauguration ceremony agenda. Plans for Mamdani’s public inauguration include a ceremony on City Hall’s steps and a program of music and speeches in front of 4,000 guests gathered in City Hall Plaza. In addition, tens of thousands of people will be able to watch a livestream of what Mamdani’s team has dubbed the Inauguration of a New Era in free viewing areas set up along Broadway. Mamdani raised $2.6 million for the transition and celebrations from nearly 30,000 contributors, more than other mayors on record in this century, both by the total and single donations, according to official campaign data that presents disclosures of inaugural expenses beginning with Michael Bloomberg’s first term in 2001. Sami Zaman, the owner of Astoria’s low-key Afghan restaurant Sami’s Kabab House, where Astoria resident Mamdani filmed a campaign video with Sanders, was on the inaugural committee alongside filmmakers, writers and activists. After becoming mayor, Mamdani will move from his one-bedroom Astoria apartment, protected from sharp price hikes by the city rent-stabilization program, to Gracie Mansion, the official residence of New York City mayors on Manhattan’s upscale Upper East Side. Bankers and others in New York, the nation’s financial capital, had expressed concern about Mamdani but since his election they have explored how to work with him. The city has had another mayor associated with democratic socialism, David Dinkins. Dinkins did not make much of his association with the Democratic Socialists of America. During his 1990-1993 term he overcame budget deficits and persuaded private businesses to remain in New York, according to city archivists. Maria Tsvetkova, Reuters
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Auckland rang in 2026 with a downtown fireworks display launched from New Zealand’s tallest structure, Sky Tower, making it the first major city to greet the new year at a celebration dampened by rain.South Pacific countries are the first to bid farewell to 2025. Clocks strike midnight in Auckland, a population of 1.7 million, 18 hours before the famous ball drops in New York’s Times Square.The five-minute display involved 3,500 fireworks launched from various floors of the 240-meter (787-foot) Sky Tower. Smaller community events were canceled across New Zealand’s North Island on Wednesday due to forecasts of rain and possible thunderstorms. Australia plans defiant celebration after country’s worst mass shooting Australia’s east coast welcomes 2026 two hours after New Zealand, but in Sydney, the country’s largest city, celebrations will be held under the pall of Australia’s worst mass shooting in almost 30 years. Two gunmen targeted a Hannukah celebration at Bondi Beach on Dec. 14, killing 15 and wounding 40.A heavy police presence monitored the thousands who thronged to the downtown waterfront on Wednesday to watch a fireworks show centered on the Sydney Harbor Bridge. Many officers openly carried rapid-fire rifles, in a first for the annual event.An hour before midnight, the massacre victims will be commemorated with one minute of silence while images of a menorah are projected on the bridge pylons. The crowd has been invited to show their solidarity with Australia’s Jewish community by shining their phone torches across the harbor.New South Wales Premier Chris Minns urged Sydney residents not to stay away through fear, saying extremists would interpret smaller crowds at New Year’s Eve festivities as a victory.“We can’t be in a situation where this horrible, criminal, terrorist event changes the way we live in our beautiful city,” Minns told reporters on Wednesday.“We have to show defiance in the face of this terrible crime and say that we’re not going to be cowered by this kind of terrorism,” he added. Indonesia and Hong Kong hold subdued events In Indonesia, one of Australia’s nearest neighbors, cities scaled back New Year’s Eve festivities as a gesture of solidarity with communities devastated by catastrophic floods and landslides that struck parts of Sumatra island a month ago, claiming more than 1,100 lives.The capital, Jakarta, will not ring in 2026 with its usual fanfare, choosing instead subdued celebrations with a calm and reflective program centered on prayers for victims, city Gov. Pramono Anung said last week.Makassar Mayor Munafri Arifuddin urged residents of one of Indonesia’s largest cities to forgo parties altogether, calling for prayer and reflection instead. “Empathy and restraint are more meaningful than fireworks and crowds,” he said.Concerts and fireworks on Indonesia’s tourist island of Bali have been canceled and replaced with a cultural arts event featuring 65 groups performing traditional dances.Hong Kong, too, will ring in 2026 without the usual spectacular and colorful explosions in the sky over its iconic Victoria Harbor, after a massive fire in November killed at least 161 people.The city’s tourism board will instead host a music show featuring soft rock duo Air Supply and other singers in Central, a business district. The facades of eight landmarks will turn into giant countdown clocks presenting a three-minute light show at midnight.Many parts of Asia welcome the new year by observing age-old traditions.In Japan, crowds will gather at a Buddhist temple in Tokyo for a bell striking at midnight. In the South Korean capital Seoul, a bell tolling and countdown ceremony will be held at the Bosingak Pavilion. China’s Xi renews threats against Taiwan Chinese President Xi Jinping in a New Year’s Eve address broadcast by state media hailed his country’s technological progress in areas such as artificial intelligence and semiconductors while renewing threats against Taiwan, which it claims as part of its sovereign territory.“We Chinese on both sides of the Taiwan Strait share a bond of blood and kinship,” he said. “The reunification of our motherland, a trend of the times, is unstoppable.” China this week launched large-scale military drills around the island. Berliners celebrate in snow Tourists and Berliners alike marked the end of 2025 by enjoying snowfall, taking selfies and making snowmen in front of the German capital’s cathedral and the iconic Brandenburg Gate. The famous Berlin TV Tower was nearly invisible thanks to the falling flakes and fog. Associated Press writers around the world contributed to this report. Associated Press
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